Sigma

Magnolol

M3445 -

≥95% (HPLC), from plant

DOWNLOAD MSDS (PDF)

Synonym: 5,5′-Diallyl-2,2′-biphenyldiol

  • CAS Number: 528-43-8

  • Empirical Formula (Hill Notation): C18H18O2

  • Molecular Weight: 266.33

  • MDL number: MFCD00016658

  • PubChem Substance ID: 24896843

Magnolol ≥95% (HPLC), from plant
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Properties

Related CategoriesAntibacterial, Antibiotics, Antifungal, Antioxidant, Biochemicals Found in Plants - sorted by compound type,
biological source from plant
assay≥95% (HPLC)
storage temp.2-8°C

Description

Biochem/physiol Actions

Bioactive plant component with antifungal,1 antibacterial2 and antioxidant effects.3 Magnolol also demonstrates anti-inflammatory activity by interferring with NF-κB signaling.4

Price and Availability

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Documents

Certificate of Analysis

Certificate of Origin

Nutrition biofiles7 (841 KB )
Structure Search
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Safety Information

SymbolGHS05GHS07GHS09  GHS05, GHS07, GHS09
Signal wordDanger
Hazard statementsH315-H318-H335-H411
Precautionary statementsP261-P273-P280-P305 + P351 + P338
Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Gloves
Hazard CodesN
Risk Statements37/38-41-51/53
Safety Statements26-39-61
RIDADRUN 3077 9/PG 3
WGK Germany3
Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, PAGE, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

NF-κB and Inflammation

Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer. Oxidative cellular ...
BioFiles 2007, 2.4, 14.
Keywords: Acetylations, Adhesion, Angiogenesis, Apoptosis, Cancer, Carcinogens, Catalysis, Cell culture, Cell proliferation, Cell signaling, Cellular processes, Degradations, Diabetes, Diseases, Environmental, Gene expression, Glycosylations, High performance liquid chromatography, Inflammation, PAGE, Phosphorylations, Thin layer chromatography, Transcription, transformation

References

1. Bang, K.H., et al., Antifungal activity of magnolol and honokiol. Arch. Pharm. Res. 23, 46-9, (2000)

2. Ho., K.Y., et al., Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis. Phytother Res. 15, 139-41, (2001)

3. Lo, Y.C., et al., Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem. Pharmacol. 47, 549-53, (1994)

4. Lee, J., et al., Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-κB activation signaling. Planta Med. 71, 338-43, (2005)

Merck 14,5697


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